Santangela likely comes from Sant'Angela, meaning holy or saintly Angela, with Angela tied to angel or messenger.
Santangela likely comes from Sant'Angela, meaning holy or saintly Angela, with Angela itself tied to angel or messenger. That gives the name a devotional and European feel, as though it preserves a religious phrase that has been merged into a single personal name.
The name sounds formal and somewhat ornate, with a strong Italianate or devotional resonance. It has the gravity of saintly naming but also the warmth of a familiar feminine core. In modern use, Santangela reads as rare, pious, and elegantly compound.